Which typical antipsychotic is most associated with retinal deposits and the risk of torsades de pointe?

Chlorpromazine (Thorazine) is indeed the typical antipsychotic most associated with retinal deposits and the risk of torsades de pointe. This association is primarily due to its chemical structure and pharmacological profile. Chlorpromazine has been linked to the accumulation of deposits in the cornea and lens of the eye with long-term use, leading to potential visual disturbances and other ocular issues.

Additionally, chlorpromazine has a notable impact on the cardiac QT interval, which can predispose individuals to torsades de pointe, a type of polymorphic ventricular tachycardia that can be life-threatening. This risk is particularly concerning in patients who may have other risk factors for cardiac arrhythmias or who are on other medications that prolong the QT interval.

While other typical antipsychotics also have side effects and some associated risks, Chlorpromazine uniquely stands out in the context of retinal deposits and the specific arrhythmic risk highlighted. This clinical awareness is crucial for healthcare providers when considering long-term treatment strategies for patients receiving antipsychotic medications.