Which of the following conditions may worsen with antipsychotic administration?

The option identifying PCP toxicity as a condition that may worsen with antipsychotic administration is insightful due to the unique pharmacological interactions that can occur in such cases. Antipsychotics primarily work by antagonizing dopamine receptors, which can alter mood and perception. In the context of PCP (phencyclidine) intoxication, patients may experience severe agitation, hallucinations, and altered mental status. The administration of antipsychotics in this scenario can lead to unpredictable effects, as the pharmacodynamics of PCP may interact negatively with the effects of the antipsychotic medication, potentially exacerbating agitation and confusion.

For conditions like panic disorder, obsessive-compulsive disorder, and major depressive disorder, antipsychotics are typically not first-line treatments. While they can be used in specific scenarios—such as augmenting treatment in major depressive disorder—their primary function does not involve directly addressing the core symptoms of panic disorder or obsessive-compulsive disorder in a way that worsens those conditions. Instead, these disorders are often managed with other classes of medications, such as antidepressants or anxiolytics, which have more suitable profiles for efficacy and tolerability in treating anxiety and mood regulation. Thus, PCP toxicity stands out as a condition more likely to be negatively