Which condition is characterized by severe PMS affecting functionality?

Premenstrual Dysphoric Disorder (PMDD) is characterized by severe premenstrual syndrome (PMS) that significantly affects an individual's daily functioning. This condition goes beyond the typical symptoms of PMS, such as mood swings, irritability, and physical symptoms, and includes psychological symptoms like depression, anxiety, and irritability to a degree that causes impairment in social or work functioning.

The condition is recognized in the DSM-5 and requires a specific diagnosis based on the intense nature of symptoms that usually arise between the ovulation phase and the onset of menstruation. For diagnosis, symptoms must be present in most menstrual cycles over the course of a year and must cause significant distress or functional impairment.

In comparison, other conditions listed, such as Major Depressive Disorder or Persistent Depressive Disorder, refer to prolonged mood disorders without the cyclical pattern of PMDD. Cyclothymic Disorder involves mood fluctuations but does not specifically relate to the menstrual cycle and thus lacks the characteristic severe premenstrual distress.