Which atypical antidepressant is known to decrease seizure threshold?

Bupropion is the atypical antidepressant known for its potential to decrease the seizure threshold. This characteristic makes it particularly important for clinicians to monitor patients with a history of seizures or those at higher risk for seizure activity when prescribing this medication.

Bupropion's mechanism of action primarily involves the inhibition of norepinephrine and dopamine reuptake, which can lead to an unexpected increase in brain excitability. This effect, especially at higher doses, may contribute to the risk of seizures.

In contrast, other options like venlafaxine, desvenlafaxine, and duloxetine primarily act as serotonin and norepinephrine reuptake inhibitors without a significant direct impact on seizure threshold. Thus, while they also have their own side effects and risks, they are not typically linked to a decrease in seizure threshold in the same way that bupropion is.