What is the recommended treatment for acetaminophen (Tylenol) overdose?

The recommended treatment for acetaminophen (Tylenol) overdose is N-acetylcysteine (NAC). NAC acts as an antidote by replenishing glutathione levels, which is essential for detoxifying the harmful metabolite that acetaminophen produces when taken in excessive amounts. If administered early, typically within 8 to 10 hours after ingestion, NAC can prevent or significantly reduce liver damage that may occur due to the overdose.

In acetaminophen overdose cases, the risk of hepatotoxicity is particularly high, as the liver's capacity to process acetaminophen diminishes when the drug is taken in doses that exceed the recommended limits. NAC serves to effectively bind to and neutralize the toxic metabolites, allowing the liver to recover and function properly.

The other options mentioned have different indications. Romazicon is used for benzodiazepine reversal, sodium bicarbonate is utilized for metabolic acidosis or certain types of drug overdoses, and glucagon is primarily indicated for hypoglycemia or as a reversal agent for beta-blocker overdoses. Understanding these distinctions is crucial for effective treatment in an emergency setting involving acetaminophen toxicity.