What is the recommended first-line treatment for depression in children?

The recommended first-line treatment for depression in children is fluoxetine. This selective serotonin reuptake inhibitor (SSRI) has been extensively studied and is generally considered safe and effective for treating major depressive disorder in pediatric populations. Fluoxetine's approval for use in children and adolescents, along with its favorable side effect profile relative to other antidepressants, positions it as a frontline option.

Studies have demonstrated fluoxetine's efficacy, making it a preferred choice in clinical guidelines for the management of childhood depression. It's important for practitioners to carefully monitor children on fluoxetine for any potential side effects and to ensure proper follow-up, but its established use and positive outcomes support its role as the initial treatment option.

Other medications listed, while they may be effective in certain contexts or populations, do not hold the same level of endorsement as first-line treatment for depression specifically in children.