What is a major sign of tobacco intoxication related to cardiovascular response?

The main sign of tobacco intoxication that relates to cardiovascular response is an increased heart rate, often referred to as tachycardia. Tobacco, particularly through nicotine, stimulates the adrenal glands to release catecholamines, which increases heart rate and blood pressure as part of the body's acute stress response.

In contrast, a decreased pulse would suggest bradycardia, which is contrary to what typically happens with tobacco use. Elevated blood pressure is also consistent with tobacco use due to similar stimulation mechanisms, but the direct and immediate cardiovascular response in the context of intoxication is primarily the increased heart rate. Respiratory failure is not a direct sign of tobacco intoxication; while smoking can lead to various chronic respiratory issues, it doesn't directly indicate an acute intoxication effect.

Therefore, the recognition of increased heart rate as a major sign of tobacco intoxication is essential in understanding its impact on cardiovascular health.