What atypical antidepressant is used to treat the negative symptoms of schizophrenia?

Mirtazapine, commonly known by its brand name Remeron, is an atypical antidepressant that has shown effectiveness in treating not only depression but also the negative symptoms of schizophrenia. Negative symptoms may include lack of motivation, social withdrawal, and difficulties in emotional expression. Mirtazapine works by altering the balance of neurotransmitters in the brain, particularly by enhancing norepinephrine and serotonin activity, which can help alleviate these deficit symptoms. Its sedative properties may also benefit patients who have concurrent insomnia or anxiety.

Other medications listed, such as citalopram, venlafaxine, and fluoxetine, are primarily focused on treating depressive disorders and may not address the full spectrum of schizophrenia symptoms, particularly the negative ones. Citalopram and fluoxetine are SSRIs that primarily increase serotonin levels, while venlafaxine is an SNRI that boosts both serotonin and norepinephrine but is not typically indicated for negative symptoms in schizophrenia. Therefore, while they can be useful for mood disorders, they do not serve the dual purpose of treating negative symptoms of schizophrenia like mirtazapine does.